Showing titles in History & Commentary

Today, astonishing surgical breakthroughs are making limb transplants, face transplants, and a host of other previously undreamed-of operations possible. But getting here has not been a simple story of medical progress. In Blood and Guts, veteran science writer Richard Hollingham weaves a compelling narrative from the key moments in surgical history. We have a ringside seat in the operating theater of University College Hospital in London as world-renowned Victorian surgeon Robert Liston performs a remarkable amputation in 30 seconds - from first cut to final stitch.

Over the past 70 years, the Diagnostic and Statistical Manual of Mental Disorders, or DSM, has evolved from a virtually unknown and little-used pamphlet to an imposing and comprehensive compendium of mental disorder. Its nearly 300 conditions have become the touchstones for the diagnoses that patients receive, students are taught, researchers study, insurers reimburse, and drug companies promote.

In Patient Zero, Richard A. McKay presents a carefully documented and sensitively written account of the life of Gaetan Dugas, a gay man whose skin cancer diagnosis in 1980 took on very different meanings as the HIV/AIDS epidemic developed - and who received widespread posthumous infamy when he was incorrectly identified as patient zero of the North American outbreak.

In mid-January 2020, scientists Ugur Sahin and Özlem Türeci learned of how a new virus that had emerged in Wuhan, China, was spreading. Recognising the threat at once, they dropped everything and committed themselves to developing a vaccine against the disease that would soon be known as COVID-19. No one believed it was possible. But by December, the revolutionary BioNTech-Pfizer mRNA inoculation became the first clinically approved COVID-19 vaccine. Soon it was being injected into the arms of millions, turning the tide on the deadliest pandemic in living memory.

Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes.

The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.

With poignant insight and humor, Frank Vertosick, Jr., MD, describes some of the greatest challenges of his career, including a six-week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22-caliber bullet lodged in his skull. Told through intimate portraits of Vertosick's patients and unsparing-yet-fascinatingly detailed descriptions of surgical procedures, When the Air Hits Your Brain illuminates both the mysteries of the mind and the realities of the operating room.

When it comes to illness, sometimes the end is just the beginning. Recovery and convalescence are words that exist at the periphery of our lives - until we are forced to contend with what they really mean. Here, GP and writer Gavin Francis explores how - and why - we get better, revealing the many shapes recovery takes, its shifting history and the frequent failure of our modern lives to make adequate space for it.

Upon it's first publication 20 years ago, And The Band Played On was quickly recognized as a masterpiece of investigatve reporting. An international best seller, a nominee for the National Book Critics Circle Award, and made into a critically acclaimed movie, Shilts' expose revealed why AIDS was allowed to spread unchecked during the early 80's while the most trusted institutions ignored or denied the threat. One of the few true modern classics, it changed and framed how AIDS was discussed.

With a death toll of between 50 and 100 million people and a global reach, the Spanish flu of 1918–1920 was the greatest human disaster. And yet, in our popular conception it exists largely as a footnote to World War I. Laura Spinney recounts the story of an overlooked pandemic, tracing it from Alaska to Brazil, from Persia to Spain and from South Africa to Odessa. She shows how the pandemic was shaped by the interaction of a virus and the humans it encountered, and how this devastating natural experiment put both the ingenuity and the vulnerability of humans to the test.

The modern healthcare system has become proficient at staving off death with aggressive interventions. And yet, eventually everyone dies - and although most Americans say they would prefer to die peacefully at home, more than half of all deaths take place in hospitals or health care facilities. At the End of Life tackles this conundrum head on. Featuring 22 compelling personal-medical narratives, the collection explores death, dying, and palliative care, and highlights current features, flaws, and advances in the healthcare system.

Some of the cruelest deeds of Japan's war in Asia did not occur on the battlefield, but in quiet, antiseptic medical wards in obscure parts of China. Far from front lines and prying eyes, Japanese doctors and their assistants subjected human guinea pigs to gruesome medical experiments in the name of science and Japan's wartime chemical and biological warfare research. Author Hal Gold draws upon a wealth of sources to construct a portrait of the Imperial Japanese Army's most notorious medical unit, giving an overview of its history and detailing its most shocking activities.

Interweaving a grand historical narrative with cutting-edge climate science and genetic discoveries, Kyle Harper traces how the fate of Rome was decided not just by emperors, soldiers, and barbarians but also by volcanic eruptions, solar cycles, climate instability, and devastating viruses and bacteria. He takes listeners from Rome's pinnacle in the second century, when the empire seemed an invincible superpower, to its unraveling by the seventh century, when Rome was politically fragmented and materially depleted.

Causes of death have changed irrevocably across time. In the course of a few centuries we have gone from a world where disease or violence were likely to strike anyone at any age and where famine could be just one bad harvest away, to one where excess food is more of a problem than a lack of it. Why is this? This Mortal Coil explains why we died in the past, the reasons we die now and how causes of death are about to profoundly change.

The stomach is notoriously outspoken. It growls, gurgles, and grumbles while other organs remain silent. For centuries humans have puzzled over this rowdy organ, deliberating on the extent of its influence over cognition, mental wellbeing, and emotions, and wondering how the gut became so central to our sense of self. Traveling from ancient Greece to Victorian England, eighteenth-century France to modern America, historian Elsa Richardson leads us on a tour of the gut, exploring all the ways that we have imagined, theorized, and probed the mysteries of the gastroenterological system.

While much has been written about the minds and methods of the medical professionals who save our lives, precious little has been said about their emotions. Physicians are assumed to be objective, rational beings, easily able to detach as they guide patients and families through some of life’s most challenging moments. But understanding doctors’ emotional responses to the life-and-death dramas of everyday practice can make all the difference on giving and getting the best medical care.

We think of transplant surgery as one of the medical wonders of the modern world. But transplant surgery is as ancient as the pyramids, with a history more surprising than we might expect. Paul Craddock takes us on a journey - from 16th-century skin grafting to contemporary stem cell transplants - uncovering stories of operations performed by unexpected people in unexpected places.

In virtually every way that can be measured, Gen Z's mental health is worse than that of previous generations. Youth suicide rates are climbing, antidepressant prescriptions for children are common, and the proliferation of mental health diagnoses has not stopped the trend. What has gone wrong with our youth? In Bad Therapy, bestselling investigative journalist Abigail Shrier argues that the problem isn't the kids - it's the mental health experts.

In 1930s and 1940s Vienna, child psychiatrist Hans Asperger sought to define autism as a diagnostic category, aiming to treat those children, usually boys, he deemed capable of participating fully in society. Depicted as a compassionate and devoted researcher, Asperger was in fact deeply influenced by Nazi psychiatry. Although he did offer individualized care to children he deemed promising, he also prescribed harsh institutionalization and even transfer to Spiegelgrund for children with greater disabilities, who, he held, could not integrate into the community.

The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.