Showing results by narrator "Mike Cooper" in All Categories

Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and the part they may have played in the beginnings of life on our planet.

Forged during the tumultuous aftermath of Partition in 1947, the Inter-Services Intelligence Directorate (ISI) has grown to become the preeminent intelligence service in Pakistan. Its capabilities are comprehensive, its remit covers both foreign and domestic intelligence, and it is one of the most feared and respected agencies of the Global South. Pakistan's ISI provides an up-to-date and detailed introduction to the ISI and its historical evolution.

In some portraits of Henry VIII there appears another figure—a gaunt and morose-looking man with a shaved head. This is William or "Will" Somer, the king's fool, a celebrated wit who reportedly could raise Henry's spirits and spent many hours with him. Was Somer an "artificial fool," a cunning comic who could speak freely in front of the king, or a "natural fool," someone with intellectual disabilities, like many other members of the profession? Fool is the first biography of Somer—and perhaps the first of a Renaissance fool.

Behavior change is hard, but O’Mara shows that by adopting strategies that are well-founded in the science of brain and behavior, individuals and organizations can adapt to the demands of the modern world.

The more we ponder, the odder the world can seem. How do footballers get their shirt numbers? Why does having daughters make couples more likely to divorce? How do you move a horse from one country to another? What counts as a journey into space? The keen minds at the Economist contemplate all these questions and more in their quest for the globe's most extraordinary quandaries and conundrums, with bizarre facts and headscratchers that show the world is even stranger than we might have thought.

In Brainhack, creativity coach Neil Pavitt gives you tips and tricks to reprogram your brain, developing the skills and insights that can transform how you think, solve problems, and make decisions.

Immediate, visceral, and full of new analyses that defy decades of conventional wisdom, The First Clash is a superb interpretation of a conflict that indeed made the world safe for Aristotle, Plato, and our own modern democracy. But it was also a battle whose legacy and lessons have often been misunderstood—perhaps, now more than ever, at our own peril.

From Parkinson’s disease to Tourette’s syndrome and depression to psychopathy, Broken Brains reveals the mysteries of brain function - and dysfunction. In this no-nonsense introduction, Ian Mitchell takes you on a tour through the sometimes devastating and sometimes bizarre effects of what happens when brains break down.

The Victorian period may have come to an end over 120 years ago, but the Victorians continue to be a vital presence in the modern world. Contemporary Britain is still in large part Victorian in its transport networks, sewage systems, streets, and houses. Victorian cultural legacies, especially in art, science, and literature, are still celebrated. Much mythologized, inexhaustibly controversial, the Victorians are an inescapable reference point for understanding the modern histories not just of Britain and its empire, but of the world.

One hundred years after a milestone medical discovery, Insulin: The Crooked Timber tells the story of how insulin was transformed from what one clinician called "thick brown muck" into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Taking the listener on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, the book reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes.

What defines a modern short story is much more than a question of length. Despite the efforts of early pioneers like Edgar Allan Poe, the genre was originally synonymous with the anecdote or tale and seen more as entertainment than art. However it has become far more than that, and this Very Short Introduction considers afresh the form's ongoing innovations in plot construction, capacity for psychological insight, and ability to offer intensely concentrated perceptions.

As globalization creates increasing challenges to established marketing practices, marketing efforts need to reposition and adapt continuously to maintain an organization's ability to reach potential customers. This Very Short Introduction provides a general overview of the function and importance of marketing to modern organizations. Kenneth Le Meunier-FitzHugh discusses how marketing remains central to creating competitive advantage, and why it needs to be forward looking and constantly reinventing itself in line with new developments in the marketplace.

After a period of tremendous upheaval, it is necessary for organizations to transform alongside their employees and welcome new ways of working. While it is impossible to predict which changes will be successful, it is crucial for leaders to now ask: what should work look like to achieve productive, healthy, and safe organizations? In Brave New Workplace, Julian Barling argues that we should focus on creating environments in which employees can flourish, rather than relying on the resiliency of workers to withstand difficult working conditions.

Not long ago, the Solar System was the only example of a planetary system - a star and the bodies orbiting it - that we knew. Now, we know thousands of planetary systems, and have even been able to observe planetary systems at the moment of their birth.

Is the West finished as a political idea? In recent years, observers have begun pointing to signs that this transatlantic community is eroding. When the European Union expanded, the classic European nation state was in decline. Now, nationalism is on the rise. Furthermore, nations within the EU are less willing to cooperate with the US on policies that require sacrifice and risks, such as using military force alongside the US.

Inspired by the life and lyrics of David Bowie, author-illustrator Jami Gigot imagines the story of a lonely young boy enchanted by the music of the stars - yet no one else can hear the shimmy-shake rhythm that moves through his body. At first misunderstood and ignored, David ultimately finds the courage to be true to himself, sparking a dazzling revolution.

Leading transformation in teams, businesses, and organizations is complex, and leaders are expected to know how to do it. This book provides the clear thinking required to navigate this challenge. In Navigate the Swirl: 7 Crucial Conversations for Business Transformation, renowned growth and strategy leader Richard Hawkes delivers a simple and powerful framework that any team can apply to overcome the most common leadership challenges to growing and scaling companies, known as "The Swirl."

These are easily the most challenging essays on the planet. Pinwill is an original conceptual thinker with a dry sense of humor and turn of phrase. Whether its politics, national economics, history, theology, or money, his writing all comes from somewhere different. You’ll need to buy his essays to discover whether you love or hate them.

Life histories can be defined as the means by which individuals (or more precisely genotypes) vary their age- or stage-specific expenditures of reproductive effort in response to genetic, phenotypic, and environmental correlates of survival and fecundity. Life histories reflect the expression of traits most closely related to individual fitness, such as age and size at maturity, number and size of offspring, and the timing of the expression of those traits throughout an individual's life. Life-history research plays an integral role in species conservation and management.

The Other Side of the Shamans, an adult-oriented novel, is divided into two parts: the first, set at the beginning of the 18th century, follows the historically-based life of Walking Horse, a young spiritual Native American in the Ho-Chunk tribe. A prodigy with remarkable physical and mental powers, Walking Horse encounters ecstatic love and abject evil, with varying degrees of success.