Charlotte Harper, the new host of American Shadows, takes listeners on a journey into one of maritime history’s most enduring enigmas: the mysterious disappearance of the Mary Celeste's crew. The episode chronicles the ship's voyage, beginning with its departure from New York in November 1872 under Captain Benjamin Briggs, accompanied by his family and crew. The ship was well-provisioned and in excellent condition for its journey to Genoa, Italy.

However, the Mary Celeste was discovered abandoned in December 1872 by the Canadian brig Dei Gratia, drifting aimlessly in the Atlantic. Despite signs of a hasty departure—missing ship papers, a lifeboat, and open hatches—the ship was seaworthy, with untouched cargo, personal belongings, and fresh provisions. Investigators found no evidence of foul play, piracy, or natural disaster severe enough to justify the crew abandoning ship.

Charlotte explores various theories about the crew's disappearance, from plausible explanations like alcohol fumes causing a temporary evacuation or natural phenomena such as a seaquake or waterspout, to more dramatic ideas involving mass hysteria or supernatural forces. Despite extensive investigations, the mystery remains unsolved, cementing the Mary Celeste as a legendary "ghost ship."

The episode reflects on the story’s lasting legacy in maritime lore and popular culture, highlighting our enduring fascination with unsolved mysteries. Harper closes with an invitation to continue exploring history's enigmatic tales on American Shadows.