For decades, dietary guidelines—and the Food Pyramid in particular—have been at the center of heated debates and considerable controversy. These guidelines have often been accused of being influenced by industry interests, oversimplifying nutritional nuance, or even directly contributing to rising obesity and metabolic disease rates.

In this episode, we critically assess common claims surrounding the Food Pyramid, including whether it was truly shaped by vested industry interests, if it encouraged harmful dietary shifts toward excessive carbohydrate and sugar consumption, and whether the subsequent health outcomes seen at the population level can be fairly attributed to these guidelines.

Additionally, we evaluate the role of the sugar industry in funding key studies and publications, examining the implications such conflicts of interest may have had on nutritional science.

Drawing on historical context, rigorous examination of scientific evidence, and an evaluation of how nutritional recommendations have evolved, this discussion aims to clarify misunderstandings, highlight legitimate criticisms, and separate fact from persistent myths regarding dietary guidance and its implications for health.

• [01:37] Common claims and narratives
• [03:15] Historical context of dietary guidelines
• [21:57] Sugar industry influence on dietary research
• [36:17] The mcgovern report
• [40:49] Misconceptions about dietary guidelines
• [44:28] Changes in food supply and consumption
• [58:15] Critiques and conflicts of interest
• [01:06:47] Key ideas segment (Premium-only)

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• Examine is the best online database for looking at the evidence of diets, foods and supplements on a range of health outcomes.

Inflammation has become a nutrition buzzword, often used in extreme or misleading ways. This episode aims to clarify what inflammation is, how it relates to diet and health, and whether specific foods truly provoke inflammatory responses in the body.

The episode provides a nuanced, evidence-based look at inflammation and diet. It explains the difference between acute and chronic inflammation, outlines the role of chronic low-grade inflammation in disease, and emphasizes that overall dietary patterns – rather than any single food – are what influence our inflammatory status.

Commonly demonized foods (such as sugar, wheat, and dairy) are scrutinized, and the conversation debunks myths about them being uniformly “inflammatory.” In this episode, Danny takes a look at what the scientific evidence actually shows about anti-inflammatory diets.

Note: This is a Premium-exclusive episode.

• 01:06 Understanding Inflammation: Basics and Biomarkers
• 04:02 Acute vs. Chronic Inflammation
• 14:21 Biomarkers of Inflammation
• 22:51 Dietary Patterns and Inflammation
• 34:53 Specific Foods and Nutrients Impacting Inflammation
• 47:01 Practical Takeaways for an Anti-Inflammatory Diet
• 51:30 Conclusion

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• Related podcast episodes:
  • 329: Diet & Inflammation
  • 353: James Hébert, ScD – Dietary Inflammatory Index
• Sigma Statement: Nutrition & Immune Function
• The Dietary Inflammatory Index (DII) – Hébert et al., 2019

GLP-1 receptor agonists have changed the landscape of obesity treatment, offering levels of weight loss once thought unattainable without surgery. But what happens after the weight is lost? And can we really talk about success without talking about maintenance?

While much of the public discourse fixates on dramatic weight loss numbers, the harder question is what comes next. Can lifestyle interventions alone sustain weight loss after GLP-1 cessation? How do metabolic adaptations and behavioral relapse factor in? And what does the data actually show about relapse rates, nutritional adequacy, and lean mass preservation when using these medications?

In this episode, Danny sits down with Tara Schmidt, dietitian at the Mayo Clinic, to examine the intersection of pharmacology and behavior in long-term weight management.

Tara Schmidt is a registered dietitian and an instructor of nutrition at Mayo Clinic. As the lead dietitian for the Mayo Clinic Diet, she provides guidance rooted in evidence-based principles. She hosts the Mayo Clinic On Nutrition podcast and co-authored The Mayo Clinic Diet: Weight Loss Medications Edition.

• [05:17] Understanding weight loss maintenance
• [08:44] Defining success in weight loss maintenance
• [11:54] Predictors of maintenance: self-monitoring and behavioral strategies
• [23:37] Pharmacological interventions: GLP-1 receptor agonists
• [31:06] Dietary considerations for those taking GLP-1 RAs
• [37:07] Addressing misconceptions about weight loss drugs
• [42:48] Final thoughts and takeaways
• [48:49] Key ideas (Premium-only)

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Zinc is an essential micronutrient that often flies under the radar, despite being vital for hundreds of enzymes and transcription factors involved in immunity, antioxidant defense, and DNA repair.

A surprisingly large segment of the population may not get enough – an estimated 10% of U.S. individuals consume less than half the recommended zinc intake, putting them at risk of deficiency.

In this episode, Prof. Emily Ho discusses how even mild zinc insufficiency can impair immune function, promote chronic inflammation, and accelerate aspects of aging. She delves into the concept of “inflammaging” – the chronic, low-grade inflammation that develops with age – and explains how inadequate zinc status can aggravate this process.

The conversation also highlights emerging research on zinc’s role in DNA integrity and how restoring zinc levels can reverse certain damage, underscoring zinc’s broader significance in healthy aging and disease prevention.

Overall, this episode provides a deep scientific look at why maintaining adequate zinc status is crucial for immune resilience and mitigating age-related inflammatory and oxidative damage.

About the Guest

Emily Ho, PhD is the Director of the Linus Pauling Institute and professor in the College of Health at Oregon State University. Her research focuses on understanding the mechanisms by which nutrient status and healthy foods affect the initiation and/or progression of chronic diseases such as cancer.

Her work has helped drive dietary requirements and recommendations for micronutrients such as zinc for communities with susceptibility to poor nutrition.

• [02:10] Interview begins
• [03:58] The roles of zinc
• [06:31] Zinc deficiency and insufficiency
• [14:26] Prevalence and risk factors of zinc deficiency
• [21:12] Zinc and age-related inflammation
• [29:39] Zinc’s impact on chronic diseases
• [31:20] Practical advice on zinc supplementation
• [41:14] Final thoughts

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• Linus Pauling Institute (LPI) Website
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• Top 10 Micronutrients for Healthy Aging
• Webinars on LPI YouTube

In this episode, we take a deep dive into the commonly held belief that protein is the most satiating macronutrient. It’s an idea that shows up frequently in both clinical guidance and popular nutrition discourse: if you want to feel fuller, eat more protein. But how robust is that claim when you drill into the details of the evidence?

To explore this, Alan and Danny examine the complex interplay between protein intake, satiety, and energy intake. We look at both historical and recent literature, including work from Kevin Hall’s group, that raises important questions about how much of protein’s supposed appetite-suppressing effect is due to the protein itself versus other influential variables—such as eating rate, food texture, and energy density.

This is an important topic, not just for academic curiosity, but for its practical implications. If our assumptions about protein and satiety are oversimplified or overstated, that has knock-on effects for how we design diets aimed at appetite regulation, weight management, or obesity prevention.

So whether you’re a researcher, a clinician, or simply someone interested in understanding the mechanisms behind how we eat, this episode aims to provide clarity on where the science currently stands—and where it might be leading.

• [03:18] The impact of protein on satiety
• [04:49] Historical context of protein and satiety
• [07:30] Mechanisms of protein-induced satiety
• [16:31] Research methods and measurements
• [21:39] Studies on protein and satiety
• [27:51] Analyzing specific studies
• [35:51] Understanding high protein meals and their effects
• [37:31] Acute vs. chronic effects of high protein intake
• [45:59] Other meal characteristics
• [53:21] Real-world implications of protein intake
• [01:01:19] Summarizing the impact of protein on satiety

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• Go to episode page
• Related studies:
  • Fazzino et al., Nature Food, volume 4, pages144–147 (2023)
  • Weigle et al., Am J Clin Nutr. 2005 Jul;82(1):41-8
  • Smeets et al., J Nutr. 2008 Apr;138(4):698-702
  • Blatt et al., J Am Diet Assoc. 2011 Feb;111(2):290-4.

Global food systems have been increasingly subjected to financial speculation, leading to adverse consequences for growers, consumers, and public health. But what are the systemic vulnerabilities that impact food security, equitable access to nutritious food, and the broader socio-political frameworks influencing these outcomes?

Understanding the financial mechanisms shaping food production and distribution is highly relevant for health professionals, policy makers, and researchers concerned with nutrition, equity, and global health systems.

This episode urges a critical re-evaluation of current food policies and invites consideration of more ethical, resilient approaches to safeguarding food systems.

Professor Martin Caraher is Emeritus Professor of Food and Health Policy at the Centre for Food Policy, City St. Georges, University of London. His research encompasses food poverty, food security, the role of food aid, and the broader implications of food systems on public health.

• [01:12] Financialization of food: an overview
• [05:27] Speculation and its impact on food prices
• [13:10] Global food security and policy responses
• [17:20] Corporate concentration in food systems
• [34:03] Potential solutions and future directions

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• Prof. Caraher’s Recommended Reading List
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• Episode #344: Prof. Martin Caraher – Food Poverty & Food Aid Provision
• X: @MartinCaraher and @NutritionDanny

Seed oils have recently become a hotly debated topic in nutrition, fueled by sensational claims on social media. In this episode, the central theme is examining whether seed oils are truly harmful or if they’ve been unjustly demonized.

The discussion tackles prevalent claims – that seed oils drive inflammation, oxidation, and chronic disease – and compares them against the current scientific evidence.

This is highly relevant to nutrition science and clinical practice today, as many patients and practitioners are encountering conflicting information about vegetable oils.

By exploring the origins of seed oils, their biochemical effects, health outcome data, and the misinformation ecosystem, the episode aims to clarify how omega-6 rich seed oils fit into a healthy diet and what evidence-based guidelines say.

• 01:00 Understanding terms: PUFA, Linoleic Acid, Omega-6
• 05:20 Do seed oils cause inflammation?
• 12:44 Omega-3 and omega-6
• 16:43 Inflammatory markers and linoleic acid
• 19:22 Oxidation and cooking oils
• 26:25 Refining processes and health concerns
• 30:32 Health outcomes and polyunsaturated fats
• 35:18 Evidence cited by anti-seed oil proponents
• 43:48 Conclusions

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• Sigma Statement: Seed Oils on Trial: Is the Panic Justified?
• Related podcast episodes:
  • 502: Sydney Diet-Heart Study – Is Linoleic Acid Causing Heart Disease?
  • 504: Vegetable Oil vs. Saturated Fat – Analysis of the LA Veterans Study
  • 505: Oslo Diet-Heart Study: Cholesterol-lowering Diets & Cardiovascular Events
  • 329: Diet & Inflammation

In this Quack Asylum episode, Danny and Alan critically examine the claims surrounding “detoxification protocols” – specialized diets, cleanses, or supplements marketed to eliminate toxins from the body for better health.

The central theme is whether these detox plans actually improve health outcomes or if they’re built on pseudoscience and fear.

Many alternative health proponents argue that modern life exposes us to countless toxins that accumulate in our bodies, causing chronic diseases, and thus we must undergo periodic detox regimens to cleanse ourselves.

There is genuine concern about environmental pollutants and chemicals – indeed, numerous substances in our food, water, and air can be harmful at sufficient doses​. Nutritional science also recognizes that certain nutrients (e.g. vitamins, antioxidants) play roles in the body’s natural detox pathways. However, there’s a large gap between acknowledging real toxic exposures versus endorsing commercial “detox” diets or products.

Many people, including health professionals, encounter patients or clients interested in detox plans, so understanding the science (or lack thereof) behind these claims is important.

• [03:20] Claim 1 – Mark Hyman
• [06:10] The purpose of today’s episode
• [08:22] Claim 2 – Chris Kresser
• [11:30] Detoxification Pathways in the Body
• [25:46] Glutathione, heavy metals and other nutrients
• [50:30] Do nutrients support detox pathways
• [55:20] Unhinged claims: Mold and mycotoxin toxicity
• [01:04:54] One more unhinged claim
• [01:09:10] Conclusions

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